Radio-frequency ablation triggers the immune defense

Recent research data indicate prolonged survival of patients suffering from various types of cancer treated using RFA (see references). Thus, concerning patients with early breast cancer heat treatment instead of surgical removal of the tumor can be regarded as an additional benefit for curative treatment.

The RFA ablation method has the potential to kill remaining cancerous cells such as local metastases and remote metastases that have not been killed in the actual ablation.

The reason is that the method is based on the stimulation of the immune system which forms antibodies that kill the cancer cells. For this to happen, the immune system must be able to distinguish the cancer cells from healthy cells, both in terms of DNA, RNA and proteins.

Normally, the cells are so tightly packed that the immune system has difficulty detecting different molecules in them. With heat treatment the cancer specific molecules are easier to detect. Thus, the immune system can find cells with different molecules, i.e. cancer cells, and kill them by forming antibodies.

REFERENCES:

Living longer: Colon cancer patients gain time with radiofrequency ablation treatment. Science News, March 30, 2010.

Longterm survival outcomes of patients undergoing treatment with radiofrequency ablation for hepatocellular carcinoma and metastatic colorectal cancer liver tumors. Iswanto Sucandy et al., International Hepato-Pancreato-Biliary Association, Published by Elsevier Ltd., june 2016.

Immune Response After Radiofrequency Ablation and Surgical Resection in Nonsmall Cell Lung Cancer. Thomas Schneider et al., Seminars in Thoracic and Cardiovascular Surgery, Volume 28, Issue 2, 2016.

Ultrasound-guided radiofrequency ablation enhances natural killer-mediated antitumor immunity against liver-cancer. Zelai Mo et al., Oncology Lekers 15: 7014-7020, 2018.

Heat induced denaturation of cells

TriMed® is a heat induced denaturation of cells. By using Micro pulse Precision Placement (MPP) combined with Anti-Seeding (AS) and True Temperature Measurement (TTM), the method addresses the difficulties using conventional RFA treatment.

The TriMed® method is simple, painless and fast. Thanks to its simplicity the patients can return home or even go to work immediately after the treatment. Under local anaesthesia with guidance from real time ultrasound the treatment electrode is precision placed under full inertia stabilization in the center of gravity of the tumor. Under the procedure anti seeding is administrated. A conventional examination room is sufficient for the procedure.

The tumor is heated to 70 0 C for 5 to 15 minutes. A surrounding spherical few millimetre thick safety zone is simultaneously heated to 43.5 0 C. When the adequate dose is given the treatment is automatically halted.

Micro Pulse Precision Placement

Micro pulse technology makes precision placement possible. The handle generates the micro pulse movements into the electrode, making penetration of hard calcified fibrous tumor tissue easy despite the tumors elastically anchorage.

True Temperature Measurement

Using true temperature measurement all temperatures will be maintained at a precision level without non linear phenomena and well proportional to differences in load due to variations in blood perfusion and passive transport.

Anti-Seeding

When the electrode is entering the tumor energy will be deposed to the tissue meaning a risk of dissemination which in turn is reduced using fast heat-pulses. Anti-seeding denature viable cancer cells.